Argireline Anti Aging
In a clinical study published in the International Journal of Cosmetic Science, Argireline was shown to reduce wrinkles up to 30% after only 30 days of use. Argireline reduces the depth of expression wrinkles, especially in the forehead and around the eyes. Argireline is a safer, cheaper, and milder alternative to Botox®, topically targeting the same wrinkle-formation mechanism in a very different way.
Argireline works by reducing the depth of wrinkles on the face caused by the contraction of muscles that cause facial expression, especially where they are most prominent, such as the forehead and around the eyes. Studies also showed Argireline can prevent apparent aging in the skin cause by repeated facial expressions, and the release of a substance called catecholamine inside the body that leads to skin aging.
Argireline’s specific sequence was discovered within a combinatorial library of hexapeptides developed by Lipotec, SA (Barcelona, Spain). Several proprietary processes led to the identification of this particular acetylated hexapeptide, which was shown to inhibit the SNARE complex formation and to also inhibit catecholamine release in high throughput screening conducted on chromaffin cells.
Once identified, the biologically active hexapeptide was synthesized by solid phase peptide synthesis using the Fmoc/tBu protocol. The peptide was purified and characterized by amino acid analysis, mass spectroscopy and NMR. Homogeneity of the peptide was assessed by HPLC and capillary electrophoresis.
Argireline was found to inhibit vesicle docking by preventing the formation of the essential ternary SNARE Complex. Inhibition of noradrenaline and adrenaline release was also demonstrated in a second in vitro study supporting the anti-wrinkle activity observed in a thirty (30) day clinical study. In vivo tests further demonstrated the benefits of Argireline. Skin topography analysis (for measuring the effectiveness of an O/W emulsion containing 5% Argireline) was performed using silicon replicas from around the eyes of ten healthy female volunteers. Replicas were obtained at 0, 15 and 30 days of a twice-a-day treatment regimen. Analyses of the imprints were performed by confocal laser scanning microscopy to assess the evolution of the skin surface before and after treatment. Skin topography images from the three dimensional reconstruction of optical sections are available upon request. It was observed that the severity of wrinkles around the eyes decreased up to 17% after 15 days of treatment and up to 27% after 30 days of treatment, substantiating the proposed biochemical mechanism hypothesis.
Anti-Aging Store Products That Contain Argireline
Collagen HydroFirm Moisturizer
Hydrofirm AM/PM contains a proprietary blend of anti-aging ingredients including key skin care vitamins and potent antioxidants, providing your skin the necessary nutrients to protect itself, enhancing your complexion. At the same time, it works to reduce wrinkles as well as diminish age spots, blemishes, and other pigment issues. Read more…
Instant Face Lift
This revolutionary age-reversal technology works by reducing facial movements naturally while restoring Collagen and healthy compounds to your skin. The results are fast and amazing! Read more…
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I have used this Argireline in an attempt to decrease my visible effects of aging by reducing the deep wrinkles and lines that occur around my forehead and eyes. I feel this product was the safest, and am happy with the results.
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